Dr. Nicholas L. Abbott
John T. and Magdalen L. Sobota Professor
Department of Chemical and Biological Engineering
University of Wisconsin, Madison

Lecture Title: Using Liquid Crystallinity to Engineer Interfaces between Synthetic and Biological Materials

Date, Time & Place: Thursday, October 18, 2007, 10:30 AM, Chemical Engineering Auditorium (IQ-04)

Abstract: **

This presentation will address the spontaneous assembly of amphiphiles and biological macromolecules at interfaces between thermotropic liquid crystalline phases and immiscible aqueous phases. This assembly process gives rise to patterned orientations of the liquid crystals that reflect the spatial and temporal organization of the amphiphiles and macromolecules. Strong and weak specific binding events involving proteins at these interfaces drive the reorganization of phospholipids and trigger orientational transitions in the liquid crystals. Because these interfaces are fluid, processes involving the lateral organization of proteins (e.g., formation of protein and phospholipid-rich domains) are also readily imaged via the orientational response of the liquid crystal, as are stereospecific enzymatic events. These results suggest new principles for designing interfaces between synthetic and biological systems.